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 Effect of 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside on lipoprotein oxidation and...........
Department of Pharmacology, Tongji Medical college of Huazhong University of Science and Technology, Wuhan, China.To investigate the effects of 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside (THSG), a compound extracted from the root of Polygonum multiflorum Thunb, on lipoprotein (LDL and VLDL) oxidation, proliferation and nitric oxide (NO) content of coronary arterial smooth cells (CASMCs) induced by LDL, VLDL, ox-LDL and ox-VLDL. The oxidation level of lipoprotein was determined by thiobab  Leggi tutto il post...
 Categoria: - sabato, 13 giu 2009 Ore. 03.42
Serum lipids--Research on the Effect of Salvia Miltiorrhiza Bge. on Blood Fat and Blood Glucose ....Abstract:
Objective To explore the effects of Salvia miltiorrhiza Bge. on blood fat, blood glucose of the hyperlipidemia rats.
Methods: The male wistar rats were fed with high fat forage for 2 months to establish the model of hyperlipidemia. Then the rats were randomly divided into normal control, model, drug, drug control groups and the contents of TC, TG, HDL C, and GLU in different groups were detected.
Results Compared with model group, the contents of TC, TG and Glu decreased obviously i Leggi tutto il post...
Categoria: - sabato, 13 giu 2009 Ore. 03.40
Synthesis and antiviral properties of some polyphenols related to Salvia genus.Laboratoire de Chimie Organique et Macromoléculaire, UMR CNRS 8009, USTL, 59655 Villeneuve d'Ascq, France.
An efficient synthesis of the acid part of salvianolic acid E 2 is described. Compound 2 was obtained from vanillin in 10 steps and 21% overall yield. During the synthesis of 2 an unexpected 5-oxo-4b,9b-dihydroindano[1,2-b]benzofuran rac-12 was isolated. Both compounds together with the acid part of salvianolic acid D were active as HIV-1 integrase inhibitors at the submicromolar level. Bu Leggi tutto il post...
Categoria: - sabato, 13 giu 2009 Ore. 03.38
Traditional Chinese medicine causing hepatotoxicity in patients with chronic hepatitis B infection: Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong. BACKGROUND: Safety of traditional Chinese medicine in patients with chronic hepatitis B is unknown. AIM: To study the clinical outcome of traditional Chinese medicine-induced hepatotoxicity in chronic hepatitis B patients. PATIENTS AND METHODS: All chronic hepatitis B patients in 2004 with liver dysfunction requiring hospitalization were screened prospectively for traditional Chinese medicine inta Leggi tutto il post...
Categoria: - sabato, 13 giu 2009 Ore. 03.35
Effects of curcumin on peroxisome proliferator-activated receptor gamma expression and nuclear......Institute of Liver Diseases, Shuguang Hospital, Shanghai University of TCM, Shanghai 201203, China.
BACKGROUND: The function of peroxisome proliferator-activated receptor gamma (PPARgamma) in hepatic fibrogenesis remains largely unknown. Curcumin is a natural substance extracted form Curcuma Longa Linn and has a variety of pharmacological effects. In this study, the effects of curcumin on the proliferation, activation and apoptosis of rat hepatic stellate cells (HSCs) through PPARgamma signalin Leggi tutto il post...
Categoria: - sabato, 13 giu 2009 Ore. 03.33
Diabetic Brain--Effects of the Leaf Aqueous Extract in Salvia miltiorrhiza Bge, on Brain Impairment Abstract:
Objective To study the effects of leaf aqueous extraction Salvia miltiorrhiza Bge. on brain impairment in diabetic rats.
Methods The diabetic model was through a high fat forage and STZ intravenous injection in wistar rats. The contents of SOD, MDA, NO in brain after drug treatment were determined.
Results The activity of SOD decreased significantly and the contents of MDA and NO increased greatly in the model groups. The results were reversed after treatment by aqueous extract of S Leggi tutto il post...
Categoria: - sabato, 13 giu 2009 Ore. 03.31
Diabetic Brain--Effects of the Leaf Aqueous Extract in Salvia miltiorrhiza Bge, on Brain ...........Abstract:
Objective To study the effects of leaf aqueous extraction Salvia miltiorrhiza Bge. on brain impairment in diabetic rats.
Methods The diabetic model was through a high fat forage and STZ intravenous injection in wistar rats. The contents of SOD, MDA, NO in brain after drug treatment were determined.
Results The activity of SOD decreased significantly and the contents of MDA and NO increased greatly in the model groups. The results were reversed after treatment by aqueous extract of S Leggi tutto il post...
Categoria: - lunedì, 01 giu 2009 Ore. 03.49
Advancement in analysis of Salvia miltiorrhiza Bge. Radix et Rhizoma.Shanghai R&D Center for Standardization of Traditional Chinese Medicines, Shanghai University of Traditional Chinese Medicine, No. 1200 Cai Lun Road, Zhangjiang Hi-Tech Park, Shanghai, 201203, China.
This review summarizes the recent advances in the chemical analysis of Salvia miltiorrhiza Bge. and its finished products, including the introduction of the identified bioactive components, analytical methods for quantitative determination of target analytes and fingerprinting authenti Leggi tutto il post...
Categoria: - lunedì, 01 giu 2009 Ore. 03.48
[Salvianolic acid A inhibits nucleoside transport and potentiates the antitumor activity ........[Salvianolic acid A inhibits nucleoside transport and potentiates the antitumor activity of chemotherapeutic drugs]
[Article in Chinese]
Zhang SH, Su J.
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
AIM: To investigate the inhibitory activity of salvianolic acid A (SAA) on nucleoside transport in cancer cells and its antitumor effect. METHODS: [3H] thymidine and [3H] uridine transport assays were used to det Leggi tutto il post...
Categoria: - lunedì, 01 giu 2009 Ore. 03.46
Salvianolic acid B in vitro inhibited matrix metalloproteinases-1, -2, and -9 activities.Department of Pathology, School of Preclinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China.
OBJECTIVE: Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases, which as a group can degrade essentially all extracellular matrix components. The proteolytic property of the MMPs is important during wound healing to remove debris and facilitate cell migration. Targeting towards the decreased MMPs activities is a new treatment strategy for healing chr Leggi tutto il post...
Categoria: - venerdì, 29 mag 2009 Ore. 03.28
Protective effect of salvianolic acid B on chronic pancreatitis induced by trinitrobenzene sulfonic Departments of Gastroenterology, Second Affiliated Hospital, Zhejiang University, Hangzhou, China. xinliang.lu@yahoo.com
OBJECTIVES: To investigate the effects of salvianolic acid B (Sal-B) on pancreatic damage in experimental chronic pancreatitis. METHODS: Chronic pancreatitis was induced by infusion of trinitrobenzene sulfonic acid into the pancreatic duct in male Sprague-Dawley rats. From the beginning of 5 weeks, the rats in group 2 were treated with Sal-B by gavage for 8 weeks. Salvianolic Leggi tutto il post...
Categoria: - venerdì, 29 mag 2009 Ore. 03.27
Effect of protocatechualdehyde on receptor for advanced glycation end products and TGF-beta1 .......Kim YS, Kim NH, Lee SW, Lee YM, Jang DS, Kim JS.Department of Herbal Pharmaceutical Development, Korea Institute of Oriental Medicine, 461-24 Jeonmin-dong, Daejeon 305-811, Republic of Korea.Advanced glycation end products and transforming growth factor-beta (TGF-beta) have been implicated in the development of diabetic complications such as cataract. The diverse metabolic effects of protocatechualdehyde (PCA, 3, 4-dihydroxybenzaldehyde) include the inhibition of aldose reductase and oxidation, Leggi tutto il post...
Categoria: - martedì, 26 mag 2009 Ore. 04.37
Effects of four medicinal herbs on human vascular endothelial cells in culture.Department of Medicine, Monash University Central and Eastern Clinical School, Prahran, Melbourne, Victoria, Australia. shanhong.ling@med.monash.edu.auBACKGROUND: Danshen (DS, Salvia miltiorrhiza), Shanchi (SQ, Panax notoginseng), Shanzai (SZ, Hawthorn) and Heshouwu (HSW, Polygonum multiflorum Thunb) are four medicinal herbs commonly used in traditional Chinese medicine and previously shown to have activity that may contribute to cardiovascular protection. This study aims to investigate effects Leggi tutto il post...
Categoria: - martedì, 26 mag 2009 Ore. 04.35
Components--LC-MS/MS-based Measurement of Salvia miltiorrhiza Bge. Phenolic Acids in PlasmaAIM: To develop sensetive and specific LC-MS/MS-based methods for measurement of plasma tanshinol (TSN), protocatechualdehyde (PCA), and salvianolic acid A, B, and D (SAA, SAB, and SAD) in supporting the pharmacokinetic evaluation of Cardiotonic(superscript ®) pills, a standardized Salvia miltiorrhiza Bge.-containing cardiovascular phytomedicine.
METHODS: Electrospray ionization (ESI) patterns and efficiency of the analytes, along with their fragmentation, were investigated to achieve sensitiv Leggi tutto il post...
Categoria: - martedì, 26 mag 2009 Ore. 04.33
[Effect of danshensu, protocatechualdehyde and Salvia miltiorrhiza Bge. injection on calcium.......[Effect of danshensu, protocatechualdehyde and Salvia miltiorrhiza Bge. injection on calcium ion concentration in cytoplasm of human erythrocytes][Article in Chinese]Shen LH, Wang BY, Wang CQ, Xie XL, Yu GR, Yao ZY, Zhu YL, Yang BJ.Department of Cadiology, Renji Hospital of Shanghai Second Medical University, Shanghai 200001, China. shenlinghong@medmail.com.cnOBJECTIVE: To study the predominant calcium-antagonist components of Salvia miltiorrhiza Bge. injection.
METHOD: The effects of danshensu Leggi tutto il post...
Categoria: - martedì, 26 mag 2009 Ore. 04.30
The effect of the major components of Salvia miltiorrhiza Bge. on bone marrow cells.Key Lab of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
Salvia miltiorrhiza Bge. (SMB), a traditional Chinese medicinal herb, has been alleged to support bone healing. However, the effects of the isolated major components of SMB on osseous cells and their corresponding effective doses are still unclear. In the present study, the effects of three components of SMB, including tanshinon Leggi tutto il post...
Categoria: - martedì, 26 mag 2009 Ore. 04.23
Antiproliferative activity of protocatechualdehyde on Chinese hamster cells grown in culture.The mode of cytotoxic action of protocatechualdehyde on V79 cells was examined. The cytotoxicity of protocatechualdehyde on V79 cells was time- and cell cycle-dependent. The lethal action is selective for the cells at S phase only. The cells lethally damaged at S phase seemed to complete their DNA synthesis, although the rate of DNA synthesis became lower and the duration of S phase was prolonged. Some cells arriving at G2 phase directly entered the next S phase without cell division and died of Leggi tutto il post...
Categoria: - martedì, 26 mag 2009 Ore. 04.22
Component--Salvianolic Acid B inhibits platelet adhesion under conditions of flow by a mechanism....Component--Salvianolic Acid B inhibits platelet adhesion under conditions of flow by a mechanism involving the collagen receptor a2ß1
Abstract
Salvianolic acid B (SAB) is a component of Salvia miltiorrhiza Bge., a herb widely used in Chinese medicine, and was previously shown to exert a number of biological activities including inhibition of platelet function, but the exact mechanisms involved are unclear. SAB dose-dependently inhibited platelet deposition from flowing, anticoagulated whole bl Leggi tutto il post...
Categoria: - martedì, 26 mag 2009 Ore. 04.17
Protective effects of 2,3,5,4'-tetrahydroxystilbene-2-O-beta-d-glucosideDepartment of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, Wuhan, PR China.Reactive oxygen metabolites (ROMs) and inducible nitric oxide synthase (iNOS) are involved in pathogenesis of inflammatory bowel disease. In this study, we examined the effects of 2,3,5,4'-tetrahydroxystilbene-2-O-beta-D-glucoside (THSG), an active component extracted from Polygonum multiflorum Thunb, on acetic acid-induced acute colitis and mitomycin C-induced chr Leggi tutto il post...
Categoria: - martedì, 26 mag 2009 Ore. 04.12
Salvianolic acid B inhibits Abeta fibril formation and disaggregates preformed fibrils and protects School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
One of the major pathological features of Alzheimer's disease (AD) is the appearance of senile plaques characterized by extracellular aggregation of amyloid beta-peptide (Abeta) fibrils. Inhibition of Abeta fibril aggregation is therefore viewed as one possible method to halt the progression of AD. Salvianolic acid B (Sal B) is an active ingredient isolated from Salvia miltiorrhiza, a Chinese herbal medici Leggi tutto il post...
Categoria: - martedì, 26 mag 2009 Ore. 04.09
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