AIM: To develop sensetive and specific LC-MS/MS-based methods for measurement of plasma tanshinol (TSN), protocatechualdehyde (PCA), and salvianolic acid A, B, and D (SAA, SAB, and SAD) in supporting the pharmacokinetic evaluation of Cardiotonic(superscript ®) pills, a standardized Salvia miltiorrhiza Bge.-containing cardiovascular phytomedicine. METHODS: Electrospray ionization (ESI) patterns and efficiency of the analytes, along with their fragmentation, were investigated to achieve sensitiv 
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